NSES Content Standard B 
Physical Science: Structure and properties of matter
Grades 9-12, page 179

The physical properties of compounds reflect the nature of the interactions among its molecules. These interactions are determined by the structure of the molecule, including the constituent atoms and the distances and angles between them.

Benchmark 4D The Physical Setting: Structure of Matter
Grades 9-12, page 80
The configuration of atoms in a molecule determines the molecule's properties. Shapes are particularly important in how large molecules interact with others.