Benchmark 6E
The Human Organism: Physical Health
Grades 3-5, page 144

Tobacco, alcohol, other drugs, and certain poisons in the environment (pesticides, lead) can harm human beings and other living things.
 

NSES Content Standard F 
Science in Personal and Social Perspectives: Personal health
Grades K-4, page 140
Different substances can damage the body and how it functions. Such substances include tobacco, alcohol, over-the-counter medicines, and illicit drugs. Students should understand that some substances, such as prescription drugs, can be beneficial, but that any substance can be harmful if used inappropriately.

NSES Content Standard F 
Science in Personal and Social Perspectives: Personal health
Grades 5-8, page 168
Alcohol and other drugs are often abused substances. Such drugs change how the body functions and can lead to addiction.

NSES Content Standard F 
Science in Personal and Social Perspectives: Personal and community health
Grades 9-12, page 197
An individual's mood and behavior may be modified by substances. The modification may be beneficial or detrimental depending on the motives, type of substance, duration of use, pattern of use, level of influence, and short- and long-term effects. Students should understand that drugs can result in physical dependence and can increase the risk of injury, accidents, and death.