Benchmark 5B
The Living Environment: Heredity
Grades 9-12, page 108

Some new gene combinations make little difference, some can produce organisms with new and perhaps enhanced capabilities, and some can be deleterious.

NSES Content Standard C
Life Science: The molecular basis of heredity 
Grades 9-12, page 185 
Changes in DNA (mutations) occur spontaneously at low rates. Some of these changes make no difference to the organism, whereas others can change cells and organisms. Only mutations in germ cells can create the variation that changes an organism's offspring.